Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
Author: Glenda Montgomery
Human immunodeficiency virus (HIV) type 1 Vpu is an integral membrane protein with a singular affinity for betaTrCP (TrCP), a key member of the SkpI-Cullin-F-box E3 ubiquitin ligase advanced that’s concerned in the regulated degradation of mobile proteins, together with IkappaB. Remarkably, Vpu is immune to…
NEDD8 is a ubiquitin-like molecule that may be covalently conjugated to a restricted quantity of mobile proteins, akin to Cdc53/cullin. We have beforehand reported that the C terminus of NEDD8 is effectively processed to reveal Gly-76, which is required for conjugation…
The Forkhead box m1 (Foxm1) gene is crucial for G(1)/S transition and essential for mitotic progression. However, the transcriptional mechanisms downstream of FoxM1 that management these cell cycle occasions stay to be decided. Here, we present that each early-passage Foxm1(-)(/)(-) mouse embryonic fibroblasts (MEFs)…