PSMA7

Description: A sandwich quantitative ELISA assay kit for detection of Human Proteasome Subunit Alpha Type 7 (PSMa7) in samples from tissue homogenates, cell lysates or other biological fluids.

Description: Rabbit polyclonal PSMA7 antibody

Description: Mouse monoclonal PSMA7 antibody

Description: Mouse monoclonal PSMA7 antibody

Description: PSMA7 Antibody detects endogenous levels of total PSMA7.

Description: A polyclonal antibody against PSMA7. Recognizes PSMA7 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200

Description: A polyclonal antibody against PSMA7. Recognizes PSMA7 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

Description: Mouse polyclonal to PSMA7

Description: Rabbit polyclonal to PSMA7

Description: Rabbit polyclonal to PSMA7

Description: Mouse polyclonal to PSMA7

Description: kits suitable for this type of research

Description: Antibody raised against PSMA7

Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9.

Description: Purified recombinant Human PSMA7 protein

Description: A polyclonal antibody against PSMA7. Recognizes PSMA7 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against PSMA7. Recognizes PSMA7 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against PSMA7. Recognizes PSMA7 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: Mouse monoclonal to PSMA7

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Description: reagents widely cited

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Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.5 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.10"Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7."_x005F_x005F_x000D_Cho S., Choi Y.J., Kim J.M., Jeong S.T., Kim J.H., Kim S.H., Ryu S.E._x005F_x005F_x000D_FEBS Lett. 498:62-66(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH HIF1A.Ref.11"Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation."_x005F_x005F_x000D_Kruger M., Beger C., Welch P.J., Barber J.R., Manns M.P., Wong-Staal F._x005F_x005F_x000D_Mol. Cell. Biol. 21:8357-8364(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.13"Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells."_x005F_x005F_x000D_Lin H.K., Altuwaijri S., Lin W.J., Kan P.Y., Collins L.L., Chang C._x005F_x005F_x000D_J. Biol. Chem. 277:36570-36576(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.23"Negative regulation of MAVS-mediated innate immune response by PSMA7."_x005F_x005F_x000D_Jia Y., Song T., Wei C., Ni C., Zheng Z., Xu Q., Ma H., Li L., Zhang Y., He X., Xu Y., Shi W., Zhong H._x005F_x005F_x000D_J. Immunol. 183:4241-4248(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH MAVS.Ref.24"PSMA7, a potential biomarker of diseases."_x005F_x005F_x000D_Du H., Huang X., Wang S., Wu Y., Xu W., Li M._x005F_x005F_x000D_Protein Pept. Lett. 16:486-489(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.059 ng/mL

Description: Description of target: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.055 ng/mL