Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation

The t(7;11)(p15;p15) translocation, noticed in acute myelogenous leukemia and myelodysplastic syndrome, genecharges a chimeric gene the place the 5′ portion of the sequence encoding the human nucleoporin NUP98 protein is fused to the three’ area of HOXA9. Here, we present that retroviral-mediated enforced expression of the NUP98-HOXA9…